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KMID : 0043320090320111573
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Archives of Pharmacal Research
2009 Volume.32 No. 11 p.1573 ~ p.1579
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Steroids and Triterpenes from the Fruit Bodies of Ganoderma lucidum and their Anti-complement Activity
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Min Byung-Sun
Seo Hyo-Won
Hung Tran Manh
Na Min-Kyun
Jung Hyun-Ju
Kim Jin-Cheol
Choi Jae-Sue
Kim Jung-Hee
Lee Hyeong-Kyu
Lee Ik-Soo
Bae Ki-Hwan
Hattori Masao
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Abstract
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To determine the anti-complement activity of natural triterpenes, chromatographic separation of the EtOAc-soluble fraction from the fruiting body of Ganoderma lucidum led to the isolation of three steroids and five triterpenoids. They were identified as ergosterol peroxide (1), ergosterol (2), genoderic acid Sz (3), stella sterol (4), ganoderic aic C1 (5), ganoderic acid A (6), methyl ganoderate A (7), and lucidenic acid A (8) based on spectroscopic evidence and physicochemical properties. These compounds were examined for their anti-complement activity against the classical pathway of the complement system. Compounds 2 and 3 showed potent anti-complement activity with IC50 values of 52.0 and 44.6 μM, respectively. Compound 1 exhibited significant inhibitory activity with an IC50 value of 126.8 μM, whereas compounds 4-8 were inactive. Our findings suggested that in addition to the ketone group at C-3, the Δ7(8), Δ9(11)-lanostadiene type triterpene also plays an important role in inhibiting the hemolytic activity of human serum against erythrocytes.
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KEYWORD
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Ganoderma lucidum, Polyporaceae, Ganoderic acid Sz, Lanostadiene triterpene, Anti-complementary activity
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